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The mechanism of action of sildenafil and its subsequent potential indications (X-inhibition; increased; created with BioRender version, Bio Rad 2024). The discovery of phosphodiesterase 5 inhibitors (PDE5 inhibitors) for causing the erection of the penis was accidental, noticed as a side effect while being administered to investigate their ability to treat hypertension and angina. Phosphodiesterase 5 Inhibitors (PDE5Is) are now widely used in the management of erectile dysfunction. This activity illustrates the indications, mechanism of sildenafil mechanism 2.3 Dosage Adjustments in Specific Situations. Sildenafil tablets was shown to potentiate the hypotensive effects of nitrates and its administration in patients who use nitric oxide donors such as organic nitrates or organic nitrites in any form is therefore contraindicated [see Contraindications (4.1), Drug Interactions (7.1), and Clinical Pharmacology (12.2)]. This review focuses on biochemical and pharmacological features of sildenafil, the active component in Viagra, interaction of sildenafil with phosphodiesterase 5, pharmacokinetic PDE5 inhibitors, such as sildenafil, essentially inhibit the off switch for cavernous relaxation, thus potentiating erection. Protein kinase G is activated by cGMP, inducing