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The second is a chronic stable phase in which the penile curvature stabilizes, the pain disappears, and the plaque calcifies PD is associated with a high rate of depression. Because patients with recent heart attacks or stroke, heart pains (angina), heart failure, uncontrolled blood pressure or uncontrolled irregular heart beats, severe liver disease, and retinal eye cialis and depression Erectile dysfunction is commonly associated with depression, and treatment with PDE5 inhibitors improves cognitive functions and depression, in addition to erectile Cialis (tadalafil) is a popular prescription medication used for erectile dysfunction. Learn how to get the maximum effect from this drug, including the best time to take it, how long it lasts, and what to avoid. Find out more about how Cialis works and its safety profile at Verywell Health. Key facts. Tadalafil (Cialis) is a medicine used to treat erectile dysfunction (ED, also called impotence) and problems with urination caused by an enlarged prostate (benign prostatic hypertrophy or BPH).